Clinical and autonomic features of patients with autonomic failure

Patient no	Sex	Final diagnosis	Present age (y)	Follow up (y)	AF onset (y)	RBD onset (y)	C sign onset (y)	E sign onset (y)	SPD (mm Hg)	DPD (mm Hg)	Rest NA (pg/ml)	Tilt NA (pg/ml)	Δ NA (pg/ml)
1	M	PAF	67	5	52	—	—	—	−61	−24	38	60	+22
2	M	PAF	67	5	62	—	—	—	−85	−31	38	65	+27
3	M	PAF	46	6	37	—	—	—	−40	−20	37	144	+107
4	F	PAF	71	6	63	—	—	—	−76	−23	187	122	−65
5	F	PAF	74	7	56	—	—	—	−54	−15	24	24	0
6	M	PAF	55	5	46	—	—	—	−80	−35	16	27	+11
7	F	MSA	58	3	52	52	58	—	−27	0	72	126	+54
8	M	MSA	71	6	60	40	68	68	−106	−51	72	86	+14
9	M	MSA	61	3	55	54	56	56	−24	−6	229	402	+173
10	M	MSA	67	2	64	60	—	65	−49	−11	226	406	+180

AF onset=age at onset of autonomic failure; RBD onset=age at onset of RBD; follow up=duration of observation from first presentation at our Institute until final diagnosis; C sign onset=age at onset of cerebellar signs; E sign onset=age at onset of extrapyramidal signs; SPD=systolic blood pressure decrease (mm Hg) on tilt test at the first observation; DPD=diastolic blood pressure decrease (mm Hg) on tilt test at the first observation; rest NA=noradrenaline concentrations at rest (supine) at the first observation (normal values from 29 age matched healthy controls: 242 (SD 100) pg/ml; range 108-500 pg/ml); tilt NA=norepinephrine concentrations after 10 minutes head up tilt at the first observation (normal values from 29 age matched healthy controls: 441 (SD 147) pg/ml; range 246-836 pg/ml); ΔNA=difference in noradrenaline concentrations between 10 minutes head up tilt and baseline values at the first observation (normal values from 29 age matched healthy controls: 199 (SD 77 pg/ml) range 111-366 pg/ml).