Correlation between CSF polymerase chain reaction (PCR) results for the detection of Esptein-Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV) DNA and clinical manifestations in 115 patients infected with HIV
| Diagnosis | Patients (n) | EBV DNA in CSF (supernatant) | KSHV DNA in CSF (pellet) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Detected | Not Detected | Detected | Not Detected | ||||||
| Lymphoma: | |||||||||
| Cerebral | 7 | 7 | 0 | 0 | 5 | ||||
| Cerebral and systemic | 2 | 2 | 0 | 0 | 1 | ||||
| Systemic | 10 | 0 | 10 | 1 | 6 | ||||
| Total | 19 | 9 | 10 | 1 | 12 | ||||
| Other neurological conditions: | |||||||||
| HADC | 27 | 1 | 26 | 0 | 9 | ||||
| Cryptococcal meningitis | 17 | 0 | 17 | 0 | 1 | ||||
| CMV encephalitis (one also had CMV polyradiculopathy) | 13 | 2 | 11 | 0 | 3 | ||||
| CMV retinitis (two also had CMV polyradiculopathy) | 7 | 3 | 4 | 1 | 2 | ||||
| Self limiting headache | 6 | 1 | 5 | 0 | 3 | ||||
| Toxoplasmosis | 3 | 1 | 2 | 0 | 1 | ||||
| Mononeuneuritis multiplex | 2 | 0 | 2 | 0 | 0 | ||||
| Transient ischaemic attack | 2 | 0 | 2 | 0 | 0 | ||||
| Sepsis, or confusional state | 2 | 0 | 2 | 0 | 1 | ||||
| Isolated cranial nerve palsy | 2 | 0 | 2 | 0 | 0 | ||||
| Acute retinal necrosis | 2 | 0 | 2 | 0 | 0 | ||||
| Disseminated MAI infection | 2 | 0 | 2 | 0 | 0 | ||||
| TB meningitis | 1 | 1 | 0 | 0 | 1 | ||||
| Myelopathy | 1 | 0 | 1 | 0 | 1 | ||||
| Miscellaneous conditions | 9 | 0 | 9 | 0 | 0 | ||||
| Total | 96 | 9 | 87 | 1 | 22 | ||||
HADC = HIV associated dementia complex; CMV = cytomegalovirus; MAI = Mycobacterium avium-intracellulare; TB = Mycobacterium tuberculosis.
Miscellaneous conditions includes a single case each of sinusitis, prolapsed intervertebral disc, postviral encephalitis, idiopathic epilepsy, viral encephalitis (aetiology undetermined), disseminated Hodgkin’s disease, disseminated extraneural cryptococcosis, and cerebellar astrocytoma.