Sensitivity and specificity of CSF-tau in a population based sample
| Group | No | CSF-tau (pg/ml) (mean (SD)) | Increase (%) | Sensitivity (%) | Specificity (%) | Positive predictive value (%) |
|---|---|---|---|---|---|---|
| AD | 43 | 796 (382) | 419 | 95 | 48 | |
| MIX | 11 | 756 (296) | 398 | 100 | ||
| VAD | 21 | 708 (382) | 373 | 14 | ||
| ALS | 9 | 386 (135) | 203 | 33 | ||
| Neurological controls | 18 | 356 (193) | 187 | 56 | ||
| Healthy controls | 18 | 190 (57) | 94 |
CSF = cerebrospinal fluid; AD = Alzheimer’s disease; MIX = mixed Alzheimer and vascular dementia; VAD = vascular dementia; ALS = amyotrophic lateral sclerosis; sensitivity = proportion of AD cases with high CSF-tau concentrations; specificity = proportion of patients with other diagnoses with normal CSF-tau concentrations; positive predictive value = proportion of correctly diagnosed AD patients of all studied (diseased) patients.