Table 3

Factors influencing survival from AIDS to onset of brain disease

Covariate		Total brain disease			HIV dementia			Opportunistic brain disease
Covariate		Relative risk	95% CI		p Value	Relative risk		95% CI	p Value	Relative risk	95% CI	p Value
Older age	1.028	1.008–1.048	0.006	1.052	1.021- 1.084	0.001	1.013	0.987–1.039	0.335
Increased CD4 at AIDS	0.995	0.993–0.997	0.001	0.996	0.996–0.999	0.015	0.994	0.992–0.997	0.001
No ZDV treatmentv:	1
ZDV before AIDS	0.805	0.489–1.326	0.395	0.605	0.244–1.503	0.279	0.897	0.493–1.633	0.722
ZDV before and after AIDS	0.551	0.360–0.843	0.006	0.524	0.258–1.063	0.073	0.548	0.322–0.931	0.026
ZDV in AIDS^3-152	0.272	0.165–0.449	0.001	0.361	0.171–0.763	0.007	0.209	0.105–0.415	0.001

3-150 Analysis based on 914 cases with available CD4 count.
3-151 Time by treatment interaction (relative risk = 1.213, p= 0.017) in analysis of total brain disease.
↵3-152 Time by treatment interaction (relative risk = 1.318, p= 0.036) in analysis of total brain disease.
ZDV=zidovudine.