Table 4

Factors influencing survival from first CD4 count below 200 cells/ μl (CD4<200) to onset of brain disease

Covariate^4-150		Total brain disease			HIV dementia			Opportunistic brain disease
Covariate^4-150		Relative risk	95% CI		p Value	Relative risk		95% CI	p Value	Relative risk	95% CI	p Value
Older age	1.013	0.993–1.033	0.196	1.019	0.985–1.055	0.282	1.001	0.975–1.028	0.942
Increased CD4 at AIDS	0.998	0.996–1.000	0.048	0.998	0.994–1.001	0.189	0.997	0.994–0.999	0.025
No ZDV treatmentv:	1			1			1
ZDV before AIDS^4-151	0.222	0.091–0.540	0.001	0.355	0.132–0.957	0.041	0.208	0.071–0.607	0.004
ZDV before and after AIDS^4-152	0.290	0.144–0.584	0.001	0.474	0.228–0.984	0.045	0.143	0.051–0.400	0.001
ZDV in AIDS^4-153	0.153	0.065–0.359	0.001	0.389	0.176–0.863	0.020	0.077	0.021–0.284	0.001

↵4-150 Analysis based on 785 cases.
↵4-151 Time by treatment interaction (relative risk = 1.237, p= 0.039) in analysis of total brain disease.
↵4-152 Time by treatment interaction (relative risk = 1.142, p= 0.152) in analysis of total brain disease.
↵4-153 Time by treatment interaction (relative risk = 1.286, p= 0.012) in analysis of total brain disease.
ZDV=zidovudine.