Short term and long term published treatment results of Dysport and long term published treatment results of Botox in hemifacial spasm
Type of botulinum toxin | Authors | Type of study | Follow up (y) | Patients (n) | Stopped treatment (n) | Treatments (n) | NC | NC (n) | Mean dose (units) | Response rate (%) | PI | DI (months) | Long term results | Side effects (%) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Botos | Dutton et al 26 | Long term | 4 | 60 | — | 148 | — | — | — | 96.8 | — | 3.60 | — | 23 |
Taylor et al 27 | Long term | — | 130 | — | 336 | 12 | 7 | — | 98 | — | 4.23 | Sustained | 32 | |
Flanders et al 28 | Long term | 8 | 65 | 14 | — | 12 | 9 | 34 | 100 | — | 4.06 | Sustained | 8 | |
Dysport | Elston2 | Short term | — | 6 | — | — | — | — | 60 | 100 | — | 3.57 | — | — |
Chong et al 9 | Short term | — | 25 | — | — | — | — | — | 100 | — | — | — | 40 | |
Yu et al 10 | Short term | — | 12 | — | 76 | — | — | 148.82-151 | 94.7 | — | 2.52 | — | 92 | |
Elston2-150 11 | Long term | 7 | 73 | — | — | — | — | 120–160 | 75 | — | 2.80–3.50 | — | 19–33 | |
Bergh et al 8 | Long term | 5 | 40 | 12 | 144 | — | — | 53 | 100 | 90 | 4.93 | — | 22 | |
Jitpimolmard et al this paper | Long term | 7 | 175 | 17 | 883 | 21 | 21 | 92 | 97 | 77.2 | 3.4 | Sustained | 29 |
PI=peak improvement, NC=number of patients in subgroup who had completed certain number of treatments; NC (n)=number of treatments which subgroup of patients has completed; DI=duration of improvement; —= not available.
↵2-150 42 of 73 patients have been reported in 1988 and all 73 patients have been reported in 1990.
↵2-151 In the original report the dose was too low, we performed a new calculation based on weight of toxin; 1 month=4.28 weeks.