Association between originally defined risk factors and risk of recurrence after a first seizure: univariate analysis with Cox’s proportional hazards regression model
Risk factors | Rate ratio | 95% CI | p Value |
---|---|---|---|
Age at intake (n=156) | 1.02 | 0.97–1.08 | 0.43 |
Patient delay (n=156) | 0.99 | 0.97–1.00 | 0.06 |
Sex: | |||
Male (n=70) | 1.00† | ||
Female (n=86) | 0.73 | 0.48–1.12 | 0.15 |
Seizure type (description only): | 0.95 | ||
Tonic clonic (n=142) | 1.00† | ||
Complex partial (n=8) | 0.99 | 0.36–2.72 | 0.99 |
Simple partial (n=6) | 1.18 | 0.43–3.23 | 0.75 |
Seizure type (description and EEG combined): | 0.19 | ||
Generalised (n=84) | 1.00† | ||
Partial (n=63) | 1.50 | 0.97–2.33 | 0.07 |
Undefined (n=9) | 1.35 | 0.53–3.41 | 0.53 |
Aetiology: | |||
Idiopathic/cryptogenic (n=129) | 1.00† | ||
Remote symptomatic (n=27) | 2.25 | 1.37–3.70 | 0.0011-150 |
EEG1: | 0.00031-150 | ||
Normal (n=57) | 1.00† | ||
Epileptiform (n=68) | 2.45 | 1.49–4.03 | 0.00041-150 |
Other abnormalities (n=31) | 1.02 | 0.52–2.02 | 0.94 |
EEG2: | 0.051-150 | ||
Normal (n=39) | 1.00† | ||
Epileptiform (n=20) | 1.05 | 0.44–2.51 | 0.91 |
Other abnormalities (n=13) | 2.70 | 1.16–6.28 | 0.021-150 |
EEG1 and EEG2 combined: | 0.021-150 | ||
Normal (n=43) | 1.00† | ||
Epileptiform (n=88) | 2.04 | 1.18–3.52 | 0.011-150 |
Other abnormalities (n=25) | 1.18 | 0.55–2.53 | 0.66 |
CT-brain: | 0.031-150 | ||
Normal (n=100) | 1.00† | ||
Abnormal (n=12) | 1.96 | 1.00–3.87 | 0.051-150 |
Not done (n=44) | 0.69 | 0.41–1.17 | 0.17 |
Family history for epilepsy: | |||
Negative (n=141) | 1.00† | ||
Positive (n=15) | 0.77 | 0.35–1.66 | 0.50 |
History of febrile convulsions: | |||
Negative (n=139) | 1.00† | ||
Positive (n=17) | 0.82 | 0.40–1.70 | 0.59 |
State of arousal: | 0.34 | ||
Awake (n=100) | 1.00† | ||
Sleep (=42) | 0.73 | 0.44–1.22 | 0.23 |
On awakening (n=9) | 1.04 | 0.42–2.59 | 0.94 |
Unknown (n=5) | 1.87 | 0.67–5.17 | 0.23 |
↵1-150 Statistically significant. †Reference category.