Cardiovascular measures and subjective ratings during treadmill exercise (mean (SD) or median (range))
| Rest | Stage 1 | Stage 2 | Stage 3 | 85% HRmax | |
|---|---|---|---|---|---|
| Mean heart rate (b.min−1): | |||||
| Controls | 68.6 (6.9) | 105.7 (7.3) | 116.5 (7.2) | 139.4 (9.6) | 157.6 (11.6) |
| CFS | 74.9 (7.8) | 108.1 (16.2) | 117.4 (10.5) | 136.4 (12.1) | 151.1 (19.8)4-153 |
| MDD | 81.2 (15.5)4-151 | 121.6 (18.0) | 132.0 (19.0) | 142.6 (11.7) | 157.7 (8.3) |
| Mean systolic blood pressure (mm Hg): | |||||
| Controls | 118.6 (15.3) | 136.3 (13.6) | 146.8 (20.7) | 158.0 (27.7) | 154.9 (25.2) |
| CFS | 110.2 (8.3) | 131.8 (13.4) | 143.0 (13.7) | 141.0 (14.7) | 148.4 (13.3) |
| MDD | 114.2 (16.2) | 130.9 (23.4) | 142.3 (17.7) | 147.5 (1.3) | 143.3 (22.5) |
| Mean diastolic blood pressure (mm Hg): | |||||
| Controls | 79.8 (10.7) | 84.7 (11.3) | 83.8 (13.6) | 86.0 (12.3) | 87.3 (10.9) |
| CFS | 76.4 (9.5) | 85.8 (9.2) | 85.8 (8.8) | 78.5 (8.4) | 88.2 (8.6) |
| MDD | 80.6 (12.6) | 82.0 (12.0) | 84.3 (10.9) | 78.0 (2.8) | 83.8 (11.2) |
| Median rating of perceived exertion: | |||||
| Controls | 0 (0–1) | 3 (1–3) | 3 (1–4) | 3.5 (1–4) | 4 (3–6) |
| CFS | 1 (0–2) | 3.5 (2–10) | 4 (3–7) | 5 (4–10) | 8 (5–10)** ‡‡ |
| MDD | 0 (0–4) | 2.5 (2–7) | 4 (2–7) | 5 (3–6) | 5 (4–7)4-151 |
| Median rating of physical fatigue: | |||||
| Controls | 0 (0–2) | 1.5 (0–4) | 2 (0–4) | 2.5 (1–5) | 3.5 (2–6) |
| CFS | 2.5 (0–4)** | 4.5 (2–9) | 6 (4–7) | 6 (5–9) | 8 (6–9)** ‡‡ |
| MDD | 0.5 (0–6) | 3.5 (0–7) | 5 (0–7) | 5 (4–7) | 6 (4–8)†† |
| Median rating of mental fatigue: | |||||
| Controls | 0 (0–2) | 0 (0–2) | 0 (0–2) | 0 (0–3) | 0 (0–3) |
| CFS | 2.5 (0–5)** | 4 (1–5) | 4 (1–6) | 4 (1–6) | 4 (1–6)** 4-152 |
| MDD | 3 (0–5)4-151 | 1.5 (0–6) | 3 (0–7) | 4 (0–5) | 3 (0–5) |
| Median rating of mood: | |||||
| Controls | 0 (0–2) | 0 (0–1) | 0 (0–2) | 0 (0–3) | 0 (0–3) |
| CFS | 0 (0–2) | 0.5 (0–3) | 2 (0–3) | 2 (0–4) | 2 (0–4) |
| MDD | 2.5 (0–7)4-151 4-152 | 3 (0–6) | 3.5 (0–7) | 4 (0–6) | 2.5 (0–6)4-151 |
4-150 p<0.05, **p<0.01 chronic fatigue syndrome vcontrols.
↵4-151 p<0.05, ††p<0.01 major depressive disorder vcontrols.
↵4-152 p<0.01, ‡‡p<0.01chronic fatigue syndrome v major depressive disorder.
↵4-153 Two subjects with CFS did not reach 85% maximum heart rate. When removed from analysis mean heart rate for the CFS group is 158.5 (SD 12.1) b.min−1.