IPD | Controls | MSA1(SND+OPCA) | SND1 | OPCA1 | PPV3-152(IPD) | PPV3-153 (IPD+controls) | |
---|---|---|---|---|---|---|---|
0.5 Tesla n (%): | 32 | 29 | 28 | 17 | 11 | ||
Any of the significant3-151 findings | 1.5 (4.7) | 0 (0.0) | 20.5 (73.2)*** ab | 9.5 (55.9)*** ab | 11 (100)*** ab 3-150 c | 93.2 | 93.2 |
Any BG abnormalities3-151 | 0 (0.0) | 0 (0.0) | 10 (35.7)*** ab | 7 (41.2)*** ab | 3 (27.3)3-150 ab | 100.0 | 100.0 |
Any infratentorial abnormalities3-151 | 1.5 (4.7) | 0 (0.0) | 18.5 (66.1)*** ab | 7.5 (44.1)*** ab | 11 (100)*** ab ** c | 92.5 | 92.5 |
Infratentorial3-151+BG3-151abnormalities (radiological “full house”) | 0 (0.0) | 0 (0.0) | 8 (28.6)*** a ** b | 5 (29.4)** ab | 3 (27.3)3-150 ab | 100.0 | 100.0 |
Only infratentorial3-151 abnormalities | 1.5 (4.7) | 0 (0.0) | 10.5 (37.5)** a *** b | 2.5 (14.7)3-150 b | 8 (72.7)*** ab ** c | 87.5 | 87.5 |
Only BG3-151 abnormalities | 0 (0.0) | 0 (0.0) | 2 (7.1) | 2 (11.8) | 0 (0) | 100.0 | 100.0 |
None of the significant3-151 changes | 30.5 (95.3)2 | 29 (100.0)2 | 7.5 (26.8)*** ab | 7.5 (44.1)*** ab | 0 (0)*** abc | ||
1.5 Tesla n (%): | 15 | 16 | 16 | 11 | 5 | ||
Any of the significant3-151 findings | 1 (6.7) | 1.5 (9.4) | 14 (87.5)*** ab | 9 (81.8)*** ab | 5 (100)** ab | 93.3 | 84.8 |
Any BG abnormalities3-151 | 0 (0.0) | 0 (0.0) | 8 (50)3-150 ab | 6.5 (59.1)*** ab | 1.5 (30) | 100.0 | 100.0 |
Any infratentorial abnormalities3-151 | 1 (6.7) | 1.5 (9.4) | 11.5 (71.9)*** ab | 6.5 (59.1)*** ab | 5 (100)*** ab | 92.0 | 82.1 |
Infratentorial3-151+BG3-151 abnormalities (radiological “full house”) | 0 (0.0) | 0 (0.0) | 5.5 (34.4)3-150 ab | 4 (36.4)3-150 ab | 1.5 (30) | 100.0 | 100.0 |
Only infratentorial3-151 abnormalities | 1 (6.7) | 1.5 (9.4) | 6 (37.5) | 2.5 (22.7) | 3.5 (70)3-150 ab | 85.7 | 70.6 |
Only BG3-151 abnormalities | 0 (0.0) | 0 (0.0) | 2.5 (15.6) | 2.5 (22.7) | 0 (0) | 100.0 | 100.0 |
None of the significant3-151 changes | 14 (93.3)2 | 14.5 (90.6)2 | 2 (12.5)*** ab | 2 (18.2)*** ab | 0 (0)** ab |
↵3-150 ap<0.05, ** ap<0.01,*** ap<0.001 v IPD;3-150 bp<0.05, ** bp<0.01, *** bp<0.001v controls; 3-150 cp<0.05,** cp<0.01, *** cp<0.001v SND.
↵3-151 Includes only findings that occurred significantly more often in MSA patients than in control and IPD patients (hyperintense putaminal rim, putaminal atrophy and infratentorial abnormalities).
↵3-152 v IPD.
↵3-153 v IPD and controls.
SND = striatonigral degeneration, OPCA = olivopontocerebellar atrophy;1 = sensitivity, 2 = specificity (both inbold), PPV = positive predictive value (likelihood of a patient with an abnormal scan to have MSA); BG = basal ganglia.