Table 3

Abnormal findings on 0.5 and 1.5 tesla MRI in idiopathic Parkinson’s disease (IPD), control, and multiple system atrophy (MSA) patients (average of rater 1 and rater 2)

IPDControlsMSA1(SND+OPCA)SND1OPCA1PPV3-152(IPD)PPV3-153 (IPD+controls)
0.5 Tesla n (%):3229281711
 Any of the significant3-151 findings1.5 (4.7)0 (0.0)20.5 (73.2)*** ab 9.5 (55.9)*** ab 11 (100)*** ab 3-150 c 93.293.2
 Any BG abnormalities3-151 0 (0.0)0 (0.0)10 (35.7)*** ab 7 (41.2)*** ab 3 (27.3)3-150 ab 100.0100.0
 Any infratentorial abnormalities3-151 1.5 (4.7)0 (0.0)18.5 (66.1)*** ab 7.5 (44.1)*** ab 11 (100)*** ab ** c 92.592.5
 Infratentorial3-151+BG3-151abnormalities  (radiological “full house”)0 (0.0)0 (0.0)8 (28.6)*** a ** b 5 (29.4)** ab 3 (27.3)3-150 ab 100.0100.0
 Only infratentorial3-151 abnormalities1.5 (4.7)0 (0.0)10.5 (37.5)** a *** b 2.5 (14.7)3-150 b 8 (72.7)*** ab ** c 87.587.5
 Only BG3-151 abnormalities0 (0.0)0 (0.0)2 (7.1)2 (11.8)0 (0)100.0100.0
 None of the significant3-151 changes30.5 (95.3)2 29 (100.0)2 7.5 (26.8)*** ab 7.5 (44.1)*** ab 0 (0)*** abc
1.5 Tesla n (%):151616115
 Any of the significant3-151 findings1 (6.7)1.5 (9.4)14 (87.5)*** ab 9 (81.8)*** ab 5 (100)** ab 93.384.8
 Any BG abnormalities3-151 0 (0.0)0 (0.0)8 (50)3-150 ab 6.5 (59.1)*** ab 1.5 (30)100.0100.0
 Any infratentorial abnormalities3-151 1 (6.7)1.5 (9.4)11.5 (71.9)*** ab 6.5 (59.1)*** ab 5 (100)*** ab 92.082.1
 Infratentorial3-151+BG3-151 abnormalities  (radiological “full house”)0 (0.0)0 (0.0)5.5 (34.4)3-150 ab 4 (36.4)3-150 ab 1.5 (30)100.0100.0
 Only infratentorial3-151 abnormalities1 (6.7)1.5 (9.4)6 (37.5)2.5 (22.7)3.5 (70)3-150 ab 85.770.6
 Only BG3-151 abnormalities0 (0.0)0 (0.0)2.5 (15.6)2.5 (22.7)0 (0)100.0100.0
 None of the significant3-151 changes14 (93.3)2 14.5 (90.6)2 2 (12.5)*** ab 2 (18.2)*** ab 0 (0)** ab
  • 3-150 ap<0.05, ** ap<0.01,*** ap<0.001 v IPD;3-150 bp<0.05, ** bp<0.01, *** bp<0.001v controls; 3-150 cp<0.05,** cp<0.01, *** cp<0.001v SND.

  • 3-151 Includes only findings that occurred significantly more often in MSA patients than in control and IPD patients (hyperintense putaminal rim, putaminal atrophy and infratentorial abnormalities).

  • 3-152 v IPD.

  • 3-153 v IPD and controls.

  • SND = striatonigral degeneration, OPCA = olivopontocerebellar atrophy;1 = sensitivity, 2 = specificity (both inbold), PPV = positive predictive value (likelihood of a patient with an abnormal scan to have MSA); BG = basal ganglia.