Clinical features of anti-amphiphysin positive patients with paraneoplastic neurological disorders

Patient	Age/sex	Clinical syndrome	Hu-Ab	Time (months) PND/tumour	Cancer	Outcome
1	60/F	Sensorimotor neuropathy	Yes	−23	SCLC	Necropsy: PEM/SN^1-151
2	58/M	PEM/SN	Yes	−7	SCLC	Necropsy: PEM/SN^1-151
3	71/M	PEM/SN and LEMS	Yes	−17	SCLC	Necropsy: PEM/SN^1-151
4	64/M	Sensory neuropathy	No^1-150	0	SCLC	Death: pulmonary embolus
5	64/M	Cerebellar syndrome	No	−18	SCLC	Alive for 7 years
6	74/M	Opsoclonus/myoclonus	No^1-150	−1	SCLC	Necropsy: perivascular/meningeal inflammatory infiltrates. Moderate neuronal loss in dentate nucleus and Purkinje cells
7	80/F	Sensory neuropathy	Yes	n.a.	None	Necropsy: PEM/SN^**

PEM/SN=Paraneoplastic encephalomyelitis/sensory neuronopathy; LEMS=Lambert-Eaton myasthenic syndrome; SCLC=small cell lung carcinoma; NA=not applicable.
↵1-150 Patients had low titre of Hu-Ab similar to that found in 16% of SCLC without paraneoplastic neurological disorders.11
↵1-151 Necropsy findings typical of PEM/SN with multifocal inflammatory infiltrates, reactive gliosis, and neuronal loss.