Depression and outcome of ischaemic stroke in patients treated with mianserin (m) or with placebo (p)
| 0 Months | 2 Months | 6 Months | 12 Months | 18 Months | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| m | p | m | p | m | p | m | p | m | p | ||||||||||
| No of patients (%): | |||||||||||||||||||
| DSM-III-R major depression | 3 (6.7) | 2 (4.4) | 2 (4.3) | 5 (10.6) | 4 (8.3) | 3 (6.8) | 5 (10.9) | 5 (11.4) | 7 (16.3) | 7 (15.9) | |||||||||
| Mean score: | |||||||||||||||||||
| HDS | 5.33-150 | 4.6 | 4.13-150 | 4.7 | 4.1 | 4.1 | 4.3 | 3.7 | 4.6 | 4.2 | |||||||||
| BDI | 8.6 | 8.1 | 7.1 | 7.5 | 6.4 | 7.3 | 6.9 | 7.3 | 6.5 | 7.5 | |||||||||
| CGI | 1.9 | 1.8 | 1.6 | 1.8 | 1.8 | 1.6 | 1.9 | 1.7 | 2.1 | 1.9 | |||||||||
| SSS | 44.4 | 42.8 | 49.3 | 49.5 | 50.9 | 51.7 | 50.4 | 52.2 | 50.4 | 52.4 | |||||||||
| Rankin scale | 3.6 | 3.7 | 2.6 | 2.6 | 2.4 | 2.2 | 2.3 | 2.2 | 2.4 | 2.0 | |||||||||
| Barthel index | 14.9 | 13.9 | 17.6 | 18.0 | 18.7 | 19.0 | 18.9 | 19.1 | 18.9 | 19.3 | |||||||||
DSM-III-R=Diagnostic and statistical manual of mental disorders, edition 3, revised; HDS=Hamilton depression scale (21 items); BDI=Beck depression inventory (21 items); CGI=clinical global impression of depression; SSS=Scandinavian stroke scale (total score).
↵3-150 p=0.05 (change from initial assessment to 2 months).