Neurocutaneous disorders associated with peripheral neuropathy
| Disorder | Cutaneous |
|---|---|
| AIDS | Seborrheic dermatitis, verruca vulgaris, molluscum contagiosum, Kaposi sarcoma |
| Alcoholism | Telangiectasias, malar rash |
| Amyloidosis (primary) | Purpura skin folds or flat surfaces or eyelids, papules, sometimes alopecia, rarely bullae on skin or oral mucosa |
| Arsenic poisoning | Dry scaly desquamation, linear hyperpigmentation of nails, Mees lines |
| Chediak-Higashi | Partial albinism, silvery blond hair |
| Cronkhite-Canada | Alopecia, skin hyperpigmentation, onychodystrophy |
| Diabetes mellitus | Necrobiosis lipoidica diabeticorum, poorly healing ulcers |
| Diphtheria (cutaneous) | Jungle sore |
| Dysautonomia, familial | Blotching, abnormal sweating, hypohidrosis |
| Fabry Disease | Angiokeratoma |
| Flynn-Aird disease | Skin atrophy, hyperkeratosis, chronic ulceration |
| Haemochromatosis | Bronze pigmentation |
| Histiocytic reticulosis | Purpura, jaundice, erythroderma |
| Impaired long-chain fatty acid oxidation | Congenital ichthyosis, ichthyosiform erythroderma |
| Leprosy | Hypopigmentation and hyperpigmentation, leonine facies, erythema nodosum leprosum, Lucio phenomenon: arteritis of skin, vitiligo |
| Linear sebaceous nevi of Jadassohn | sebaceous and epithelial nevi, linear nevus sebaceous |
| Lyme disease | Target lesions |
| Pellagra | Erythematous photosensitive rash, erythema, vesicles, glossitis, malar and supraorbital hyperpigmentation, rhagades |
| Poems syndrome | Hyperpigmentation, thickening, verrucous angiomas, hirsutism, Raynaud’s phenomenon |
| Poikiloderma-spastic paraplegia | Poikiloderma: delicate, smooth, wasted skin |
| Refsum’s disease | Ichthyosis |
| Refsum’s disease with increased pipecolicacidaemia | Ichthyosis |
| Sarcoidosis | Hypohidrosis,, cicatricial alopecia; acute: erythema nodosum, vesicles, maculopapular rash; chronic lupus pernio, plaques, scars, keloids |
| Systemic lupus erythematosus | Photosensitivity, malar rash, discoid lupus |
| Thallium intoxication | Hair loss |
| Trichorrhexis nodosa | Ichthyosis, flexural eczema, photosensitivity, short wooly hair |
| Vitamin B12 deficiency | Black nail pigmentation (nail bed and matrix), oral aphthae |
| Werner (pangeria) | Scleroderma like skin, graying hair and baldness, leg ulcers, progressive scalp alopecia, sparse body hair, telangiectasia, mottled pigmentation; loss of subcutaneous fat, subcutaneous calcification |
| Xeroderma pigmentosum | Photosensitivity, early onset skin cancer (basal cell, squamous cell, and malignant melanoma), atrophy, telangiectasia, actinic keratosis, angioma, keratoacanthomas |