Dose requirements and efficacy of treatment in the 49 patients who received apomorphine therapy for>2 months
| Continuous infusion (n=25) | Intermittent injection (n=24) | |
|---|---|---|
| Infusion rate (mg/h) | 4.0 (2.0–6.5) | |
| Number of injections/day | 5.1 (2.0–13) | |
| Bolus dose size of apomorphine (mg) | 1.6 (0.5–4.0) | 1.9 (0.5–4.5) |
| Total daily dose of apomorphine (mg) | 112.5 (57–174) | 9.7 (2–26) |
| Number of levodopa doses/day before apomorphine | 8.0 (4–20) | 7.0 (4–15) |
| Number of levodopa doses/day with apomorphine | 7.0 (0–15) | 10.0 (5–15) |
| Total daily dose of levodopa before apomorphine (mg) | 900 (400–2600) | 825 (175–3000) |
| Total daily dose of levodopa with apomorphine (mg) | 450 (0–1900) | 1050 (200–2050) |
| Part of day in “off” before apomorphine (%) | 50.0 (21–77) | 50.0 (25–80) |
| Part of day in “off” with apomorphine (%) | 25.0 (10–50) | 29.5 (5–60) |
| Number of “off” periods before apomorphine | 4.0 (1.5–10) | 4.0 (1–8) |
| Number of “off” periods with apomorphine | 5.0 (2–20) | 5.0 (3–8) |
Data represent median (range).