Table 2

Mean (SD) normalised volumes (ml) for control subjects and all patients and mean (SD) volume changes2-151(ml and %) for all patients

ControlAllp ValueVolume change2-151
Brain stem28.1  (2.4)22.3  (3.1)<0.0001** −5.8  (3.1) −20.6%
Cerebellum147.8 (11.0)120.1 (13.7)0.0001** −27.6 (13.7) −18.7%
Upper cervical cord4.4 (0.68)2.4 (0.68)<0.0001** −2.1 (0.68) −46.4%
Cerebral grey matter590.3 (47.2)590.8 (53.5)NS+0.5 (53.5) +0.1%
Cerebral white matter465.5 (44.0)409.9 (47.1)0.0007** −55.6 (47.1) −11.9%
Cerebral hemispheres1055.8 (80.9)1000.1 (65.0)0.047* −56.0 (65.0) −5.3%
Ventricles14.8 (10.0)17.9 (11.3)NS+3.2 (11.3) +21.3%
Corpus callosum 6.4 (1.4)5.1 (1.0)0.004** −1.4 (1.0) −21.4%
  • 2-151 Mean of (individual patient volume - mean control volume);Corpus callosal area in cm2; *Trend (0.006<p<0.05); **significant after Bonferroni (p<0.006).