Table 6

Rates of volume change6-151 derived from disease duration. [Mean rates (SD) of change (ml/year) and mean % change in RR/SP patients]

RR changeSP changep Value
Brain stem−2.0  (2.1)  −6.9%/y−0.7  (0.6)  −2.5%/y0.026-150
Cerebellum−9.3 (11.4)  −6.3%/y−3.5 (2.3)  −2.3%/yNS
Upper cervical cord−0.54 (0.41)  −12.2%/y−0.27 (0.19)  −6.1%/y0.0096-150
Cerebral grey matter−3.8 (23.9)  −0.6%/y−1.4 (8.5)  −0.2%/yNS
Cerebral white matter−9.5 (16.6)  −2.0%/y−8.7 (8.2)  −1.9%/yNS
Cerebral hemispheres−14.5 (33.8)  −1.4%/y−7.3 (8.7)  −0.7%/yNS
Ventricles−0.1 (6.2)  −0.9%/y+0.6 (1.1)  +3.8%/yNS
Corpus callosum‡ −0.3 (0.46)  −5.3%/y−0.2 (0.16)  −2.8%/yNS

  • ↵6-151 Volume changes derived from table 3; ‡Corpus callosal area in cm2.

  • ↵6-150 Trend (0.006<p<0.05); **significant after Bonferroni (p<0.006).