Comparison of the results obtained in four studies using the same simulation approach in computing the statistical power for a parallel group design with follow up duration of 6 months and for expected treatment effects of 60% and 70%. The response variable studied was the number of new enhancing lesions
Sample size | Truyen et al7 (n=12) | Nauta et al6 (n=23) | Tubridy et al8 (n=31) | Present study (n=65) | |
---|---|---|---|---|---|
2×10 | 60 | - | - | - | 35 |
70 | 84 | 71 | 61 | 57 | |
2×20 | 60 | 80 | 70 | 63 | 50 |
70 | 93 | 88 | 81 | 74 | |
2×30 | 60 | 89 | 78 | 72 | 62 |
70 | 99 | 95 | 89 | 85 | |
2×40 | 60 | 94 | 87 | 83 | 74 |
70 | 99 | 100 | 95 | 92 |