Table 1

Concentrations of HIV-RNA in paired CSF and plasma samples from 17 AIDS patients with progressive multifocal leukoencephalopathy (PML). Q_Alb is also shown for each patient

Patient		CD4+ (number/μl)		Q_Alb		HIV-RNA (log ₁₀)		Antiretroviral drugs
Patient		CD4+ (number/μl)		Q_Alb		CSF	Plasma	Antiretroviral drugs	CSF/plasma ratio
1	92	NA	4.92	5.80	0.84	Refused
2	97	4.34	4.37	5.33	0.81	Naive
3	40	6.8	3.40	4.92	0.69	Naive
4	36	16.63	5.95	6.13	0.97	Naive
5	49	4.8	3.04	5.54	0.54	Naive
6	88	3	2.69	4.70	0.57	Refused
7	106	3.5	3.43	5.37	0.63	AZT
8	27	5.99	3.48	5.88	0.59	AZT+3TC
9	21	7	4.18	5.63	0.74	Refused
10	7	7.67	4.72	5.72	0.82	Naive
11	66	6.8	3.29	5.21	0.63	Discontinued
12	102	10.18	5.48	6.09	0.89	Discontinued
13	34	4.44	4.32	5.25	0.82	Naive
14	98	3.1	3.95	5.05	0.78	Discontinued
15	110	5.1	2.76	4.82	0.57	Refused
16	8	3.93	3.51	4.82	0.72	Discontinued
17	50	NA	3.63	4.63	0.78	Naive

Q _Alb =albumin concentration in CSF (mg/l)×1000/albumin concentration in serum (g/l); NA=not available; AZT=zidovudine; 3TC=lamivudine.
CSF cell count was always normal (⩽5 cells/μl); Q _Alb⩾8 signified an impaired blood-brain barrier.