Table 1

Hyperintense and hypointense lesion volume (ml) (n=67)

Hyperintense lesion volume on T2 weighted imagesHypointense lesion volume on T1 weighted images
Observation Mean (SE)13.2 (1.4)Mean (SE)3.3 (0.6)
BaselineRange1.1–48.9Range0.03–20.9
Median8.9Median1.4
End of 6 monthMean (SE)15.5 (1.6)Mean (SE)4.1 (0.7)
Range0.8–58Range0.1–23.7
Median11.1Median1.8
Mean % change1-150 +17.4Mean % change1-150 +23.6
Median % change+24.0Median % change+26.5
Treatment Mean (SE)15.2 (1.6)Mean (SE)4.2 (0.7)
End of 6 monthRange0.78–54.2Range0.07–25.9
Median9.9Median1.8
Mean % change−1.9Mean % change+2.2
Median % change−10.4Median % change0
End of 12 monthMean (SE)14.2 (1.6)Mean (SE)4.1 (0.7)
Range0.9–48.4Range0.06–25.8
Median9.5Median1.8
Mean % change−7.0Mean % change−0.1
Median % change−4.2Median % change0
  • 1-150 Change from previous scan: p<0.001, Wilcoxon signed rank test compared with previous scan.

  • SE=Standard error.