Table 2

Low (EDSS (⩽3.5, n=466) and high (EDSS>3.5, n=94) entry disability subgroups: Disability changes as measured by (A) EDSS, (B) SNRS and (C) AI, analysed using 2 year disability difference and AUC^CHANGE for all visits: median (interquartile difference) and mean (SD)

	Entry EDSS ⩽3.5 subgroup			Entry EDSS>3.5 subgroup
	Two year difference			AUC^CHANGE(in EDSS-years)			Two year difference			AUC^CHANGE(in EDSS-years)
	Median	Mean		Median	Mean		Median	Mean		median	mean
(A) EDSS:
IFNβ-1a 44 μg (3×/week)	0 (1.0)	+0.21 (1.13)		+0.04 (1.79)	+0.23 (1.58)		0 (1.0)	+0.38 (1.15)		+0.26 (1.21)	+0.83 (1.79)
IFNβ-1a 22 μg (3×/week)	0 (1.0)	+0.12 (1.27)		+0.05 (1.79)	+0.20 (1.79)		+0.5 (1.0)	+0.69 (1.30)		0 (2.10)	+1.07 (2.20)
Placebo	+0.5 (1.25)	+0.37 (1.18)		+0.38 (1.66)	+0.64 (1.84)		+0.5 (2.0)	+1.14 (1.59)		+1.07 (3.00)	+1.78 (2.28)

	Two year difference		AUC^CHANGE(in SNRS-years)			Two year difference			AUC^CHANGE(in SNRS-years)
	Median	Mean		Median	Mean		Median	Mean		median	mean
(B) SNRS:
IFNβ-1a 44 μg (3×/week)	0 (7)	−1.34 (7.66)		0 (12.68)	−1.11 (11.54)		−3 (16)	+0.07 (9.67)		+0.81 (18.74)	+0.46 (12.25)
IFNβ-1a 22 μg (3×/week)	0 (9)	−1.57 (9.15)		−0.32 (9.51)	−1.15 (11.49)		−2 (14)	−2.49 (9.12)		−0.05 (18.93)	−2.82 (15.09)
Placebo	−1 (7)	−2.49 (8.48)		−1.46 (9.86)	−2.34 (11.22)		−4 (12)	−7.00 (11.68)		−7.86 (19.65)	−8.67 (16.89)

	Two year difference			AUC^CHANGE(in AI-years)			Two year difference			AUC^CHANGE(in AI-years)
	Median	Mean		Median	Mean		Median	Mean		median	mean
(C) AI
IFNβ-1a 44 μg (3×/week)	0 (1)	+0.19 (0.93)		0 (0.86)	+0.16 (1.25)		0 (1)	+0.5 (1.07)		+0.18 (1.61)	+0.69 (1.54)
IFNβ-1a 22 μg (3×/week)	0 (1)	+0.34 (1.13)		+0.10 (0.85)	+0.41 (1.38)		+1 (1)	+0.97 (1.59)		+0.61 (1.57)	+1.10 (2.27)
Placebo	0 (1)	+0.29 (1.03)		0 (1.27)	+0.48 (1.44)		+1 (1)	+1.36 (2.18)		+1.13 (1.81)	+1.65 (2.34)