Table 2

Main areas of activation in generic brain activation maps for patients and controls

Area of activation		Approximate Brodmann area (BA)				Talairach coordinates (mm)		FPQ	Cluster size (voxels)
Area of activation		Approximate Brodmann area (BA)				x	y	FPQ	Cluster size (voxels)	z
Control subjects: left eye stmulation:
Visual cortex	17,18,19		+11	−65	+4	10.4	253
Visual cortex	17		+9	−63	+9	13.8	177
Visual cortex	18,19		−13	−56	−2	6.2	99
Visual cortex	17,18		+11	−82	−2	8.1	143
Visual cortex	17,18		+6	−68	+15	7.6	104
Visual cortex	19		−9	−70	−2	5.7	67
Control subjects: right eye stimulation:
Visual cortex	17,18,19		−11	−72	−2	10.6	257
Visual cortex	17,18		−9	−72	+4	13.9	230
Visual cortex	18,19		−2	−74	+9	7.8	175
Visual cortex	17,18		0	−75	+15	6.7	53
Visual cortex	17,18		−17	−65	−7	5.8	49
Visual cortex	19		+17	−58	−7	7.2	33
Optic neuritis: unaffected eye stimulation:
Visual cortex	17,18		0	−74	+4	10.5	195
Visual cortex	17,18		−17	−67	−2	5.6	160
Visual cortex	17,18		−11	−60	+15	7.0	121
Visual cortex	18,19		−15	−58	−7	5.6	94
Visual cortex	17		0	−74	+9	6.4	92
Visual cortex	17,18		0	−75	−2	8.6	91
Visual cortex	18		−15	−60	+9	5.8	56
Visal cortex	19		−19	−51	−13	4.5	37
Visual cortex	19		+17	−53	−13	4.1	25
Visual cortex	18		−2	−74	+20	5.0	23
Insula	14–16		+36	+28	+4	3.5	21
Optic neuritis: affected eye stimulation:
Visual cortex	17,18		+8	−58	+4	7.0	371
Visual cortex	17,18		+13	−56	+9	7.8	329
Visual cortex	18		0	−72	+15	5.6	219
Visual cortex	18		+4	−77	−2	5.3	193
Visual cortex	18		+11	−61	−7	4.0	129
Visual cortex	18,19		−13	−60	−7	4.3	106
Visual cortex	18		+6	−74	+9	5.5	95
Visual cortex	18		−15	−79	−2	4.3	68
Insula-claustrum	14–16		+32	+2	+15	3.5	78
Insula-claustrum	14–16		+26	+11	+9	3.8	75
Insula-claustrum	14–16		−36	+28	+9	3.8	71
Insula-claustrum	14–16		−42	+23	+4	3.6	47
Insula-claustrum	14–16		−38	−4	−2	3.2	46
Insula/corpus striatum	14–16		+23	+12	−2	4.2	79
Corpus striatum	—		+11	+18	+15	4.2	123
Corpus striatum	—		−32	+21	+15	4.3	80
Lateral temporal cortex	21,22		+49	−23	+9	3.7	81
Lateral temporal cortex	21,22		55	−47	+9	3.7	50
Lateral temporal cortex	21,22		53	−35	+4	3.7	44
Posterior parietal cortex	40		45	−19	+20	3.5	66
Posterior parietal cortex	40		−47	−23	+20	4.1	63
Orbitofrontal cortex	11		55	+11	+15	3.6	63
Thalamus	—		+8	−11	+9	4.5	43

FPQ is the fundamental power quotient (see text), a measure of the power of response for each cluster.