Clinical and MRI findings at baseline and year 1
| Year | PP (137) | TP (30) | ||
| EDSS | 0 Median | 6.00 (2.0–8.5) | 5.75 (2.5–8.5) | |
| 1 Median | 6.00 (2.0–9.0)1-150 | 6.00 (2.5–8.5) | ||
| Definite deterioration | 35 patients (26%) | 6 patients (20%) | ||
| New brain lesions | Mean | 0.88 (SD 1.56) | 0.47 (SD 0.63) | |
| Median | 0.00 (0–9) | 0.00 (0–2) | ||
| Brain T2 load (cm3) | 0 Mean | 11.66 (SD 13.95) | 18.16 (SD 23.13) | |
| Median | 6.65 (0–72.2)1-150 | 10.53 (0.38–102.76)1-150 | ||
| 1 Mean | 13.13 (SD 15.68) | 20.21 (SD 23.76) | ||
| Median | 7.15 (0–74.7) | 12.22 (0.39–93.35) | ||
| Change | Mean | 1.47 (SD 3.70) [16.0%] | 2.05 (SD 4.43) [12.1%] | |
| Median | 0.33 (−6.0–20.3) [7.3%] | 0.61 (−9.4–14.4) [10.8%] | ||
| Brain T1 load (cm3) | 0 Mean | 4.34 (SD 6.50) | 6.23 (SD 11.14) | |
| Median | 1.67 (0–33.3)1-150 | 2.42 (0–54.21) | ||
| 1 Mean | 4.61 (SD 6.20) | 6.64 (SD 9.87) | ||
| Median | 2.30 (0–32.9) | 3.55 (0.04–39.21) | ||
| Change | Mean | 0.26 (SD 2.03) [25.8%] | 0.41 (SD 3.74) [23.7%] | |
| Median | 0.11 (−10.0–11.3) [12.6%] | 0.24 (−15.0–10.3) [16.0%] | ||
| 6 slice brain volume (cm3) | 0 Mean | 267.49 (SD 23.26) | 265.29 (SD 21.77) | |
| Median | 269.48 (210–320)1-150 | 271.12 (205–297) | ||
| 1 Mean | 264.05 (SD 24.30) | 264.02 (SD 21.77) | ||
| Median | 265.60 (203–315) | 267.59 (209–298) | ||
| Change | Mean | −3.44 (SD 6.85) [−1.30%] | −1.28 (SD 3.37) [−0.47%] | |
| Median | −2.34 (−45.5–11.2) [−0.95%] | −1.85 (−7.5–5.9) [−0.68%] | ||
| Number of cord lesions | 0 Mean | 2.07 (SD 2.55) | 3.32 (SD 2.67) | |
| Median | 1.00 (0–12)1-150 | 2.50 (0–10) | ||
| 1 Mean | 2.22 (SD 2.56) | 3.32 (SD 2.67) | ||
| Median | 1.50 (0–12) | 2.50 (0–10) | ||
| New cord lesions | Mean | 0.14 (SD 0.34) | 0.00 (SD 0.00) | |
| Median | 0.00 (0–1) | 0.00 | ||
| Cord lesion load | 0 Mean | 2.64 (SD 3.57) | 4.02 (SD 4.56) | |
| Median | 1.5 (0–18.5)1-150 | 3.0 (0–21) | ||
| 1 Mean | 2.81 (SD 3.60) | 4.02 (SD 4.56) | ||
| Median | 1.5 (0–18.5) | 3.0 (0–21) | ||
| Increase in cord load | Mean | 0.16 (SD 0.44) | 0.00 (SD 0.00) | |
| Median | 0.00 (0–2) | 0.00 | ||
| Cord area (mm2) | 0 Mean | 73.20 (SD 9.72) | 72.27 (SD 9.05) | |
| Median | 73.27 (43.6–93.8)1-150 | 70.84 (55.8–86.8)1-150 | ||
| 1 Mean | 70.54 (SD 10.33) | 68.92 (SD 9.63) | ||
| Median | 71.2 (42.9–90.0) | 67.42 (52.8–83.0) | ||
| Change | Mean | −2.66 (SD 3.16) [−3.73%] | −3.35 (SD 2.29) [−4.75%] | |
| Median | −2.85 (−13.0–4.2) [−3.75%] | −3.32 (−7.1–1.4) [−4.91%] | ||
Definite deterioration in the EDSS is defined as an increase of 1.0 if the EDSS ⩽5 or an increase of 0.5 if >5.0.
Wilcoxon signed ranks test used to assess differences between baseline and year 1. Mann-Whitney test used to detect differences between the patient groups in absolute and % change of MR parameters.
↵1-150 p<0.01, baseline v year 1 values.