Table 2

Disease progression data for the total cohort (n=313). Comparisons of Kaplan-Meier analyses of “confirmed“ v “sustained“ progression end points, with (A) EDSS point progression and (B) worsening to EDSS 6.0

(A) EDSS point increase		Confirmed progression				Sustained progression		Log rank p value		Positive prediction of confirmed for sustained
(A) EDSS point increase		c(10%)	S(1y)			n (%)	c(10%)	Log rank p value		Positive prediction of confirmed for sustained		S(1y)	n (%)
+1.0-point 3 months	274	0.83	101 (32%)		456	0.91	48 (15%)	<0.0001	0.48
+1.0-point 6 months	457	0.94	67 (21%)		547	0.95	44 (14%)	0.024	0.67
+2.0-points 3 months	548	0.94	38 (12%)		NR	0.97	20 (6%)	0.018	0.53
+2.0-points 6 months	NR	0.98	29 (9%)		NR	0.98	16 (5%)	0.084	0.55
(B) Worsening to EDSS 6.0		Confirmed progression			Sustained progression		Log rank p value		Positive prediction of confirmed for sustained
(B) Worsening to EDSS 6.0		c(5%)	S(1y)	n (%)		c(5%)	Log rank p value		Positive prediction of confirmed for sustained		S(1y)	n (%)
3 months	526	0.96	24 (8%)		637	0.97	17 (5%)	0.265	0.71
6 months	729	0.98	17 (5%)		NR	0.98	12 (4%)	0.562	0.71
9 months	NR	0.99	12 (4%)		NR	0.99	10 (3%)	0.669	0.83
12 months	NR	1	10 (3%)		NR	1	9 (3%)	1	0.90

c=Centiles (days); S(1y)=cumulative survival probability at 1 year; n=number (and %) of patients reaching end point; NR=end point not reached.