Disease progression data for the total cohort with complete datasets (n=289). In trial disability changes of categorical EDSS trend analyses by (A) six subsets and (B) three disease course categories
| n (%) | Two year EDSS difference | AUC (in EDSS-year) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Mean (SD) | Median (Q1, Q3) | Mean (SD) | Median (Q1, Q3) | ||||||
| (A) Six subsets of EDSS trends | |||||||||
| Minimal change | 57 (20) | +0.03 (0.36) | 0 (0 to +0.5) | +0.02 (0.50) | 0 (−0.35 to +0.25) | ||||
| Sustained improvement | 17 (6) | −1.44 (0.43) | −1.5 (−2.0 to −1.0) | −2.22 (0.70) | −2.07 (−2.61 to −1.64) | ||||
| Erroneous improvement | 24 (8) | −0.27 (0.86) | 0 (−1.0 to +0.5) | −1.30 (0.54) | −1.31 (−1.63 to −0.88) | ||||
| Fluctuating course | 107 (37) | +0.12 (0.85) | 0 (−0.5 to +0.5) | +0.21 (0.67) | +0.27 (+0.26 to +0.72) | ||||
| Erroneous progression | 40 (14) | +0.53 (0.79) | +0.5 (0 to +1.0) | +1.26 (0.76) | +1.28 (+0.77 to +1.95) | ||||
| Sustained progression | 44 (15) | +2.03 (0.98) | +2.0 (+1.0 to +2.5) | +3.14 (1.58) | +2.95 (+1.83 to +4.06) | ||||
| (B) Three disease course categories | |||||||||
| Stable course | 74 (26) | −0.31 (0.73) | 0 (−0.5 to +0.5) | −0.50 (1.10) | −0.06 (−0.82 to +0.12) | ||||
| Relapsing-remitting | 171 (59) | +0.16 (0.87) | 0 (−0.5 to 0) | +0.24 (1.01) | +0.33 (−0.51 to +0.94) | ||||
| Progressive course | 44 (15) | +2.03 (0.98) | +1.5 (+1.0 to +2.5) | +3.14 (1.58) | +2.95 (+1.83 to +4.06) | ||||