Clinical characteristics and shunt response
| n (AD−/AD+) | Biopsy group | p Value between group contrast | |||||
|---|---|---|---|---|---|---|---|
| AD− | AD+ | ||||||
| Clinical characteristics at baseline: | |||||||
| Age (mean (SD)) | 33/23 | 76.15 (7.65) | 77.56 (6.54) | 0.474 | |||
| Male/female ratio | 33/23 | 21/12 | 12/11 | 0.391 | |||
| GDS (mean (SD)) | 33/23 | 4.03 (0.85) | 4.91 (1.08) | 0.001 | |||
| MMSE (mean (SD)) | 33/23 | 22.55 (4.84) | 15.91 (8.24) | 0.001 | |||
| Composite cognitive score (mean (SD)) | 21/14 | 0.16 (0.74) | −0.62 (0.72) | 0.004 | |||
| Gait velocity (cm/s; mean (SD)) | 27/16 | 71.14 (25.65) | 49.14 (34.12) | 0.021 | |||
| Ambulatory index (mean (SD)) | 26/16 | 3.15 (1.43) | 4.22 (1.66) | 0.034 | |||
| Patients with incontinence (%) | 33/23 | 73 | 74 | 0.921 | |||
| Shunt response: | |||||||
| Change in cognition | |||||||
| GDS (mean change (SD)) | 21/16 | 0.05 (0.86) | 0.00 (0.63) | 0.854 | |||
| MMSE (change (SD)) | 24/16 | −0.46 (2.72) | 0.88 (5.26) | 0.516 | |||
| Composite cognitive score (mean change in Z score (SD)) | 17/10 | 0.29 (0.32)1-160 | 0.23 (0.34)1-151 | 0.653 | |||
| Change in gait | |||||||
| Velocity (mean change; cm/s (SD)) | 19/13 | 17.36 (18.12)1-160 | 20.74 (24.68)1-150 | 0.658 | |||
| CIGC (% exhibiting moderate or marked improvement) | 21/12 | 42.8 | 41.7 | 0.947 | |||
| Ambulatory index (mean change (SD)) | 20/14 | 0.65 (1.14)1-150 | 0.86 (1.46)1-150 | 0.645 | |||
| Change in incontinence | |||||||
| Incontinent cases improved (%) | 20/14 | 65.0 | 57.1 | 0.643 | |||