Variable | Group | Baseline | Week 3 | Week 6 | Week 9 | Week 12 | Aggregate5-150 | Contrast analysis p value | |
Ashworth | Placebo | 3.6 | 3.2ø | 2.6 | 2.7 | 2.9 | 10.3 (12) | ||
BTX-A | 4.2 | 2.4ø | 2.5 | 2.9 | 3.0 | 7.8 (6) | <0.002 | ||
Range of movement | Placebo | 2.1 | 3.1 | 2.9 | 3.4 | 3.6 | 102.8 (20) | ||
BTX-A | 2.0 | 2.9 | 3.4 | 3.4 | 3.4 | 33.8 (4) | |||
Gross motor function | Placebo | 2.8 | 2.9 | 3.0 | 3.1 | 3.3 | 30.1 (40) | ||
BTX-A | 2.6 | 2.7 | 3.2 | 3.1 | 3.4 | 39.1 (40) | |||
Motor function; upper limb5-151 | Placebo | 2.5 | 3.0 | 2.9 | 3.3 | 3.2 | 11.0 (6.5) | ||
BTX-A | 2.0 | 3.0 | 3.3 | 3.5 | 3.2 | 18.0 (12.5) | |||
Motor function; limb/trunk5-152 | Placebo | 1.9 | 3.1 | 3.4 | 3.2 | 3.4 | 18.6 (16) | ||
BTX-A | 2.2 | 3.0 | 3.0 | 3.3 | 3.5 | 25.5 (21) | |||
Problem ratings | Placebo | 2.5 | 3.05-153 | 2.95-153 | 3.2 | 3.3 | 11.1 (10) | <0.05 | |
<0.01 | |||||||||
BTX-A | 1.5 | 2.75-153 | 3.45-153 | 3.7 | 3.8 | 14.5 (14) |
↵5-150 The aggregate is the sum of the raw scores for weeks 3 to 12 inclusive. The values in the aggregate column are means with medians in parentheses.
↵5-151 For patients with upper limb deficits;
↵5-152 for patients with lower limb deficits.
↵5-153 Denotes point at which a significant change from the previous value is statistically significant as detected with ANOVA performed on the ranked data and confirmed by contrast analysis.