Table 2

Homocysteine, vitamin B12, folate, SAM, and monomine metabolites in depression

Total plasma Hcy (μmol/1) Serum vitamin B12 (ng/1) Serum folate (μg/1) RBC folate (μg/1) CSF folate (μg/1) CSF SAM (nmol/1) CSF 5-HIAA (nmol/1) CSF HVA (nmol/1) CSF MHPG (nmol/1)
Normal controls (n=18)7.6 (2.4)344 (105)7.0 (3.0)362 (175)
Neurological controls (n=20)6.6 (2.0)410 (154)9.1 (3.9)373 (97)22.3 (3.8) (n=17)163 (30) (n=16)107 (23)233 (49)56.3 (18.5)
Depression:
 All patients  (n=46)13.2 (6.2)b c 361 (148)5.9 (4.0)247 (126)b d 19.4 (7.6) (n=28)146 (36) (n=28)95 (42) (n=28)211 (108) (n=28)46.2 (14.0) (n=28)
 Normal Hcy group  (n=22)8.2 (1.9)392 (133)7.2 (4.0)320 (118)21.8 (6.2) (n=15)160 (35) (n=15)104 (48) (n=15)251 (124) (n=15)48.6 (16.1)
 High hcy group  (n=24)17.7 (5.4)a c 334 (157)4.6 (3.7)d 179 (92)b c 16.6 (8.4)e (n=13)129 (29)d (n=13)85 (31)g (n=13)165 (62)e (n=13)43.5 (11.2)f (n=13)
  • Values are mean (SD). Hcy=homocysteine. Versus normal controls: a=p<0.001; b=p<0.01. Versus neurological controls: c=p<0.001; d=p<0.01; e=p<0.02; f=p<0.04; g=p<0.05.