Table 1

Studies of heparin as treatment of cerebral venous sinus thrombosis

Study	Type of the study	Number of patients	Type of heparin	Dose of heparin	Outcome assessment	Follow up oral anticoagulant
Einhaupl et al 15 1991	A mix randomised placebo-controlled and retrospective study	20 In the randomised part and 102 patients in the retrospective part	Intravenous unfractionated heparin	Bolus injection of 3000 IU followed adjusted dose heparin (25000–65000 IU/day). Low dose, intermittent dose and adjusted dose heparin in the retrospective arm.	A specially designed sinus venous thrombosis severity scale for the randomised arm	None
Brucker et al 19 1998	Retrospective study	42 Patients received heparin, no control group	Intravenous unfractionated heparin	All patients received adjusted dose heparin	Modified Rankin scale	Heparin was followed by oral anticoagulant, duration was not specified
Bruijn et al ⁵ 1999	Randomised placebo-controlled trial	60 Patients	Low molecular weight heparin	180 Anti-factor Xa units/kg/24 hour administered subcutaneous twice daily for 3 weeks	Barthel index of activities of daily living and Oxford handicap scale	3 Months of oral anticoagulant for patients allocated to low molecular weight heparin (open phase)