Studies on the psychological impact of genetic testing for Huntington's disease
| Study | Type of genetic test2-150 | Sample | Instrument2-151 | Findings2-152 | |||||
|---|---|---|---|---|---|---|---|---|---|
| 7–10 days | 12 months | ||||||||
| Wiggins et al199223 | LA | 37 Carriers | SCL-90 | Significantly higher | NS | ||||
| 58 Non-carriers | GWS | Significantly lower | |||||||
| 40 No result2-153 | BDS | Significantly higher | NS | ||||||
| Tibben et al199732 | LA | 20 Carriers | IES Avoidance | Significantly higher | NS (6 Months) | ||||
| 44 non-carriers | BHS | Significantly higher | NS (6 Months) | ||||||
| Codori et al199724 | LA MA | 52 Carriers | BDI | Not available | NS | ||||
| 108 non-carriers | BHS | Not available | Significantly higher | ||||||
| Quaid and Wesson, 199533 | LA | 5 Carriers | SCL-90 | Not available | Significantly higher | ||||
| 14 non-carriers | |||||||||
| Decruyenaere et al 199627 | LA MA | 22 Carriers | STAI | NS | NS | ||||
| 31 non-carriers | BDI | NS | NS | ||||||
| Dudok de Wit 199734 | MA | 9 Carriers | IES | NS | NS (6 Months) | ||||
| 16 non-carriers | |||||||||
↵2-150 LA=linkage analysis; MA=mutation analysis.
↵2-151 BHS=Beck hopelessness scale; BDI=Beck depression inventory; IES=impact of event scale (higher scores on these scales are equivalent to more symptoms); SCL=symptom check list; STAI=Spielberger anxiety inventory; GWS=general wellbeing scale.
↵2-152 The analyses refer to carrier vnon-carrier scores at each time point.
↵2-153 The “no result” group includes 23 testing decliners and 17 people who did not receive an informative result.