Table 1

Characteristics of studies where patients with an established clinical diagnosis of idiopathic Parkinson's disease (IPD) or another parkinsonian condition were examined for response to apomorphine, acute levodopa, or chronic levodopa

First author/ ref NoYear of publicationPatients (n)Assessment methodsThreshold for responseNumber of tests for positive resultFollow up for chronic LDDrugDose (mg)
Oertel13 1989231942Hoehn and YahrUnclearUnclearNAAPO1/2/4/5/10
Hughes14 19906535100Tapping>15%One of fourAcute LD275
12 m walk>25%APO1.5/3.0/4.5
Tremor>2 pointsVariableChronic LD<1000
Webster>3 points
D'Costa15 199120828Tapping>15%One of twoAPO1/2/4/5/8/10
6 m walk>15%1 monthChronic LDVariable
Schelosky16 1993281341UPDRS III>30%One of threeNAAPO2.0/3.5/5.0
10 m walk>15%
Bonuccelli17 199330737Tremor>25%Tremor & one otherNAAPO0.7/3.5/7.0
Linazasoro18 1993251843Tapping>15%One of threeNAAPO1.5/3/6/7.5
20 m walk>25%
Tremor>2 points
Roth19 1994231639Columbia>30%Only oneNAAPO0.05 mg/kg
Miranda20 1995221032Tapping>15%One of threeNAAPO1.5/3.0/5.0
12 m walk>25%
Webster>3 points
Zappia21 199770474UPDRS III>20%Only oneAcute LD275
6 monthsChronic LD<1000
  • APO=apomorphine; LD=levodopa; NA=not available/applicable.