Clinical features associated with drug resistance
Non-resistant | Resistant | |
Population (total=155 cases, 15 cases were pseudoresistant) | 116 (74.8%) | 24 (15.5%) |
Psychiatric disorders (χ2, p<0.0001) | 22 (19%) | 14 (58.3%) |
Severe mental retardation | 1 | 0 |
Pervasive developmental disorders | 0 | 2 |
Psychotic disorders | 2 | 0 |
Generalised anxiety | 3 | 3 |
Personality disorders | 12 | 6 |
Dependent personality | 3 | 1 |
Obsessive-compulsive personality | 0 | 1 |
Histrionic personality | 2 | 0 |
Paranoiac personality | 1 | 0 |
Borderline personality | 3 | 3 |
Personality disorder not specified | 3 | 1 |
Depressive disorders | 1 | 2 |
Tic disorders | 0 | 1 |
Enuresis | 1 | 0 |
Anorexia nervosa | 2 | 0 |
Seizure types (Fisher exact 2 by 4, p=0.0026): | ||
GTCS+AS+MJ (χ2, p<0.001) | 27 (23.3%) | 15 (62.5%) |
GTCS+MJ | 71 (61.2%) | 9 (37.5%) |
AS+MJ | 6 (5.2%) | 0 |
MJ | 12 (10.3%) | 0 |
Seizure types in patients with psychiatric problems1-150: | ||
GTCS+AS+MJ | 3 (13.7%) | 8 (57.1%) |
GTCS+MJ | 17 (77.3%) | 6 (42.9%) |
AS+MJ | 0 | 0 |
MJ | 2 (9%) | 0 |
Seizure types in patients without psychiatric problem1-150: | ||
GTCS+AS+MJ | 24 (25%) | 7 (70%) |
GTCS+MJ | 54 (57.5%) | 3 (30%) |
AS+MJ | 6 (6.5%) | 0 |
MJ | 10 (11%) | 0 |
GTCS=Generalised tonic-clonic seizures; AS=absence seizures; MJ=myoclonic jerks.
↵1-150 There is no statistical difference between the patients with and without psychiatric problems. The combination of three seizure types and the presence of psychiatric problems are independently factors of resistance.