Clinical features associated with drug resistance

Non-resistant Resistant
Population (total=155 cases, 15 cases were pseudoresistant)116 (74.8%)24 (15.5%)
Psychiatric disorders (χ2, p<0.0001)22 (19%)14 (58.3%)
 Severe mental retardation10
 Pervasive developmental disorders02
 Psychotic disorders20
 Generalised anxiety33
 Personality disorders126
  Dependent personality31
  Obsessive-compulsive personality01
  Histrionic personality20
  Paranoiac personality10
  Borderline personality33
  Personality disorder not specified31
 Depressive disorders12
 Tic disorders01
 Enuresis10
 Anorexia nervosa20
Seizure types (Fisher exact 2 by 4, p=0.0026):
 GTCS+AS+MJ (χ2, p<0.001)27 (23.3%)15 (62.5%)
 GTCS+MJ71 (61.2%)9 (37.5%)
 AS+MJ6 (5.2%)0
 MJ12 (10.3%)0
Seizure types in patients with psychiatric problems1-150:
 GTCS+AS+MJ3 (13.7%)8 (57.1%)
 GTCS+MJ17 (77.3%)6 (42.9%)
 AS+MJ00
 MJ2 (9%)0
Seizure types in patients without psychiatric problem1-150:
 GTCS+AS+MJ24 (25%)7 (70%)
 GTCS+MJ54 (57.5%)3 (30%)
 AS+MJ6 (6.5%)0
 MJ10 (11%)0
  • GTCS=Generalised tonic-clonic seizures; AS=absence seizures; MJ=myoclonic jerks.

  • 1-150 There is no statistical difference between the patients with and without psychiatric problems. The combination of three seizure types and the presence of psychiatric problems are independently factors of resistance.