Clinical signs and symptoms at onset of disease
| Initial signs/symptoms1-150 |
CJD patients (%) (n=25) |
AD patients (%) (n=19) |
DLB patients (%) (n=12) |
| Dementia only | 7 (28) | 12 (63) | 5 (42) |
| Dementia+neurological signs/symptoms | 4 (16)1-151 | 3 (16)1-151 | 2 (17)1-151 |
| Dementia (total) | 11 (44) | 15 (79) | 7 (58) |
| Gait disturbances | 7 (28) | 1 (5) | — |
| Visual disturbances | 7 (27) | — | — |
| Confusion | 4 (16) | — | — |
| Vertigo | 4 (15) | 1 (5) | — |
| Aphasia | 2 (8) | — | — |
| Behavioural changes | 2 (8) | — | — |
| Dystonia | 1 (4) | — | — |
| Hallucinations | 1 (4) | 1 (5) | — |
| Parkinsonism | 2 (8) | — | 1 (8) |
| Limb paresis | 1 (4) | — | — |
| Myoclonus | — | 1 (5) | — |
| Epileptic seizures | — | 3 (16) | — |
| Delusion | — | — | 1 (8) |
| Aggressive behaviour | — | — | 1 (8) |
| No data | — | — | 3 (25) |
↵1-150 Multiple mentioning possible.
↵1-151 Neurological signs in CJD patients were dystonia, gait disturbances, visual disturbances, and confusion; in AD patients they were myoclonus, epileptic seizures or gait disturbances; in DLB patients they were parkinsonism or visual hallucinations.
— Signs not noted.