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First choice
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Alternative
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Cryptoccocosis: |
Acute infection | Amphotericine B, 0.7 mg/kg/day iv and flucytosine, 100 mg/kg/day orally or iv in 4 divided doses for 2 weeks, then fluconazole, 400 mg orally/day for 8 weeks | Fluconazole, 400 mg orally/day for 10 weeks, or |
Fluconazole 200–400 mg orally/day for 10 weeks and flucytosine 150 mg/kg/day orally or iv in 4 divided doses for 2 weeks |
Suppressive therapy | Fluconazole 200 mg orally/day | Amphotericine B, 0.6–1.0 mg/kg iv/week, or |
Itraconazole, 200 mg orally/day |
Toxoplasmosis: |
Acute infection | Pyrimethamine 100–200 mg loading dose (2 days), then 50–100 mg orally/day plus folinic acid 10 mg orally/day+ sulfadiazine 4–8 g orally/day for at least 6 weeks | Pyrimethamine plus folinic acid plus clindamycin 900–1200 mg iv/6h or 300–450 mg orally/6h for at least 6 weeks, or |
Trimethoprim 160 mg plus sulfamethoxazole 800 mg/8h orally or iv for at least 6 weeks |
Suppressive therapy | Pyrimethamine 25–75 mg orally/day plus folinic acid 10 mg orally/day+sulfadiazine 500–1000 mg orally/6 h | Pyrimethamine plus folinic acid plus clindamycin 300–450 mg orally/6h, or |
Trimethoprim, 160 mg plus sulfamethoxazole, 800 mg orally/day |
Prophylaxis (patients with positive IgG serology and CD4 count <100/mm3) | Trimethoprim 160 mg plus sulfamethoxazole 800 mg orally /day | Dapsone 50 mg/day plus pyrimethamine 50 mg/week plus folinic acid 25 mg/week |