Demographic and neuropsychological data from the subject groups
| Test | Controls Mean (SD) |
AD Mean (SD) | Semantic dementia Mean (SD) | FvFTD Mean (SD) | ANOVA p Value |
| Male:female ratio | 10:8 | 19:11 | 9:8 | 12:1 | |
| Age (y) | 70.6 (5.7) | 70.4 (8.2) | 61.9 (6.3) | 58 (7.8) | <0.00054-150 |
| Range | 60–82 | 54–83 | 51–77 | 43–71 | |
| Duration of symptoms (y) | NA | 4.7 (2.9) | 4.8 (2.7) | 4.5 (2.4) | NS |
| Range | NA | 1–9 | 2–10 | 2–10 | |
| Duration of follow up (y) | NA | 3.6 (2.3) | 3.3 (2.4) | 2.6 (1.8) | NS |
| Range | NA | 1–8 | 1–8 | 1–8 | |
| MMSE (30) | 28 (0.97) | 22.2 (3.1) | 19.1 (7.8) | 25.6 (4.0) | <0.00054-151 |
| Range | 27–30 | 13–27 | 6–29 | 17–30 | |
| CDR | NA | 0.9 (0.7) | 0.9 (0.5) | NT | NS |
| Range | NA | 0–2 | 0.5–2 | NT | |
| Rey copy | 34.4 (1.5) | 29.4 (7.9) | 31.1 (4.6) | 32.9 (3.0) | <0.034-152 |
| Rey recall | 18.8 (5.5) | 3.8 (4.8) | 12.4 (8.4) | 17.1 (9.0) | <0.00014-152 |
| Naming (64) | 62.8 (0.9) | 58.8 (6.2) | 24.4 (26.4) | 61.3 (1.1) | <0.00014-153 |
| PPT words | 51.4 (0.9) | 49.8 (2.4) | 38.5 (8.5) | 48.5 (6.5) | <0.00014-153 |
| NPI | NT | 5.7 (9.6) | 16.0 (12.7) | 42.7 (13.6) | <0.00014-154 |
↵4-150 Semantic dementia and fvFTD groups significantly younger than controls and AD group on Tukey test (p<0.05).
↵4-151 AD and semantic dementia groups both significantly worse than control and fvFTD groups on Tukey test (p<0.05).
↵4-152 AD group significantly impaired compared with the other groups on Tukey test.
↵4-153 Semantic dementia group significantly impaired compared with the other groups on Tukey test.
↵4-154 FvFTD group significantly impaired compared with the other groups on Tukey test.
NT=not tested; NA=not applicable; AD=Alzheimer's disease; fvFTD=frontal variant frontotemporal dementia; MMSE= mini mental state examination41; CDR=clinical dementia rating35; PPT words=pyramids and palm trees test33; NPI=neuropsychiatric inventory34