Serial neuroimaging study of white matter lesions in the interval form of CO poisoning
| Study | Methods | n | Age (y) | Lucid interval | Time of initial neuroimaging | Serial changes in white matter lesions and clinical outcomes |
| Hayashi et al 14 | CT | 1 | 72 | 8 days | 11 days after the onset of sequelae | A correlation between changes in CT abnormalities (a low density area in the white matter) and clinical presentation |
| Choi et al 15 | CT | 13 | 37–78 | 13–45 days | Within 11 days after the onset of sequelae | No correlation between the CT findings and the outcome of delayed CO sequelae |
| Changet al 1 | MRI | 15 | 25–71 | 1–4 weeks | 4–9 weeks after exposure to CO during the relapse of sequelae | A decrease in extent and signal intensity of white matter lesions accompanied by a reduction of clinical symptoms |
| Kamada et al 16 | 1H-MRS | 1 | 55 | 17 days | 9 days after the onset of sequelae | Lowered NAA/Cr and increased Cho/Cr immediately after the onset of sequelae recovered, reflecting clinical improvement |