PRNP 129 genotype and allele frequency in patients with Alzheimer's disease (AD) and healthy controls (HC)
| n | Sex | PRNP 129 genotypes (%) | PRNP 129 allele frequency | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| F | M | MM | MV | VV | M | V | |||||||
| Total sample: | |||||||||||||
| AD | 212 | 130 | 82 | 126 (59) | 73 (35) | 13 (6) | 0.77 | 0.23 | |||||
| HC | 201 | 80 | 121 | 103 (51) | 78 (39) | 20 (10) | 0.71 | 0.29 | |||||
| Subjects <65 y: | |||||||||||||
| AD | 72 | 45 | 24 | 38 (53) | 29 (40) | 5 (7) | 0.73 | 0.27 | |||||
| HC | 91 | 29 | 62 | 48 (53) | 35 (38) | 8 (9) | 0.72 | 0.28 | |||||
| Subjects ⩾65 y: | |||||||||||||
| AD | 140 | 85 | 55 | 89 (63) | 44 (31)1-150 | 8 (6)1-150 | 0.79 | 0.211-151 | |||||
| HC | 110 | 51 | 59 | 55 (50) | 43 (39)1-150 | 12 (11)1-150 | 0.70 | 0.301-151 | |||||
↵1-150 p=0.044, PRNP 129 V+ v MM genotype frequency in AD⩾65 years compared with age matched HC.
↵1-151 p=0.03, PRNP 129 V/M allele frequency in AD⩾65 years compared with age matched HC.
PRNP=Prion protein gene; HC=healthy controls; F=females; M=males; AF=allele frequency; GF=genotype frequency; AD=Alzheimer's disease.