NEP genotype and the densities of SPs, NPs, and NFTs in the hippocampus and superior temporal gyrus, ages at onset and durations of illness in Alzheimer's disease
| NEP genotype | 19/19 | 19/20 | 19/21 | 20/20 | 20/21 | 20/22 | 20/23 | 21/21 | 21/23 | p value |
| Hippocampus: | ||||||||||
| SPs | 9.8 | 10.9 | 15.4 | 9.9 | 10.2 | 0.1 | 11.4 | 11.7 | 21.3 | 0.60 |
| NPs | 9.1 | 9.7 | 13.1 | 8.9 | 10.0 | 0.0 | 5.7 | 11.5 | 18.8 | 0.45 |
| NFTs | 26.3 | 17.4 | 29.1 | 27.1 | 27.2 | 0.5 | 12.1 | 29.4 | 34.7 | 0.38 |
| Superior temporal gyrus: | ||||||||||
| SPs | 20.7 | 31.0 | 57.6 | 42.3 | 30.7 | 1.3 | 52.3 | 33.0 | 63.8 | 0.46 |
| NPs | 13.0 | 9.9 | 14.0 | 13.1 | 10.8 | 0.6 | 19.5 | 19.5 | 21.8 | 0.52 |
| NFTs | 4.6 | 2.4 | 1.9 | 4.0 | 2.0 | 0.0 | 4.7 | 12.6 | 8.5 | 0.52 |
| Age at onset | 83.0 | 74.3 | 80.3 | 78.4 | 81.7 | 58.0 | 82.0 | 86.5 | 0.23 | |
| Duration of illness | 8.0 | 9.0 | 3.3 | 6.5 | 7.4 | 4.0 | 5.0 | 5.0 | 0.48 | |
Values are means. The density represents the average counts in 2.56 mm2 for SPs and NPs, and in 0.64 mm2 for NFTs. NEP=neprilysin gene; AD=Alzheimer's disease; SPs=senile plaques; NPs=senile plaques with dystrophic neurites; NFTs=neurofibrillary tangles.