Table 1

Analysis of tau in PSP

Case	Tau seq	FH	Clinical features	Age at onset	Pathological features
PSP, Progressive supranuclear palsy; AD, Alzheimer's disease; PD, Parkinson's disease; CBD, corticobasal degeneration; NINDS, National Institute for Neurological Disorders and Stroke; PSP, criteria positive for clinically probable or possible PSP; Tolosa, Tolosa criteria for PSP positive.
1	N	−ve	Atypical: IPD-like	53	Typical
2	N	−ve	Typical: Tolosa	72	Typical
3	N	−ve	Atypical: IPD-like	76	Typical+vascular disease
4	N	−ve	Typical: NINDS	62	Typical
5	N	−ve	Typica: Tolosal	66	Typical
6	N	−ve	Atypical: gait disorder without documented eye movement disorder	77	Typical+cortical involvement
7	N	−ve	Atypical: chorea	60	Typical
8	N	+ve: 1 brother and father tremor	Typical: Tolosa	63	Typical+CBD features
9	N	+ve: 1 brother parkinsonism	Atypical: IPD-like	79	Typical
10	N	+ve: father and nephew parkinsonism	Typical: NINDS	66	Typical
11	N	+ve: sister AD	Typical: NINDS	69	Typical
12	N	+ve: uncle PD	Typical: NINDS	66	Typical
13	N	+ve: brother parkinsonism	Typical: NINDS	73	Typical
14	N	+ve: mother and father tremor	Atypical: non–levodopa responsive parkinsonism	70	Typical
15	N	+ve: brother PSP, brother AD	Typical: NINDS	67	Not available
16	N	+ve: cousin PSP	Typical: NINDS	64	Typical