Table 2

Changes in excitatory, inhibitory, and non-transmitter amino acid concentrations after an acute ischaemic insult in three patients (A, B, C) during aneurysm surgery (CMA70 10 mm catheter perfused with Ringer's solution at 1 μl/min)

Patient A concentration (μM)Patient B concentration (μM)Patient C concentration (μM) illustrative case 3
Amino acid typeAmino acid nameBaseline → ischaemiaRatioBaseline → ischaemiaRatioBaseline → ischaemiaRatio
The number preceding the arrow represents the baseline value, the number after the arrow represents the value during the ischaemic insult. The ratio is the ischaemia value/baseline value. Note the relatively larger increases in GABA concentration compared with the other amino acids. Patient C is illustrative case history 3. Alanine, arginine, and phenylalanine measurements were not available (NA) in patient B.
ExcitatoryGlutamate18→492.77.8→303.811→938.1
Aspartate5.4→101.99.6→141.57.8→192.5
InhibitoryGABA0.08→0.82100.14→0.956.80.01→141350
Glycine25→230.922→381.717→181.1
Taurine14→100.71.5→6.54.310→181.7
Non-transmitterAlanine33→310.9NA14→221.6
Arginine11→8.70.8NA9.2→101.1
Asparagine3.5→3.00.92.8→6.02.18.4→222.6
Citrulline2.2→1.60.71.5→4.63.11.5→1.61.0
Glutamine171→1190.787→1992.3151→2401.6
Histidine18→120.75.7→132.31.2→0.010.01
Methionine2.7→2.711.8→5.32.93.9→5.31.4
Phenylalanine8.0→6.60.8NA7.6→152.0
Serine14→141.032→511.617→150.9
Threonine29→401.410→252.57.6→8.21.1
Tryptophan2.5→1.90.84.9→142.93.4→4.71.4
Tyrosine7.3→5.90.86.3→121.94.6→5.31.2
Valine32→290.915→443.021→241.2