Table 1

Receptor binding profiles of antipsychotic drugs16*

Affinity for receptor (Ki (nmol/l))
DrugD1D2D4α1α2H15-HT2a5-HT2cM
*Information from premarketing trials and product monograph.
D1, D2, D4 , dopamine receptors; α1, α2, adrenergic receptors; M, muscarinergic receptor; 5-HT2a, 5-HT2c, serotonin receptors ; H, Histamine receptors.
Haloperidol251546360>100078>1000570
Clozapine8512697861281.0
Risperidone7537231550.626>1000
Olanzapine31112271922874112.1
Quetiapine455160NA7871122061556