Effect of antpsychotic drugs in behavioural models of extrapyramidal syndrome
| Drug | Effect on conditioned avoidance in rats (ED50 (mg/kg)) | Catalepsy scores in rats (ED50 (mg/kg)) |
|---|---|---|
| Reproduced from Kerwin and Taylor 1996.16 | ||
| Haloperidol | 0.28 | 0.74 |
| Clozapine | 33.5 | >8 |
| Risperidone | 1.3 | 4.3 |
| Olanzapine | 5.6 | 23 |
| Quetiapine | 108 | (80 mg quetiapine produces 37.9 s catalepsy compared with 36.5 s for 4 mg haloperidol and 9.5 s for 80 mg clozapine) |