Table 3

Side effects associated with action on different receptors

Receptor systemEffects
Blockade of α1 adrenergic receptorsPostural hypotension, reflex tachycardia
Stimulation of serotonin 5-HT1 receptorsAntidepressant, anxiolytic effect, hypophagia
Stimulation of serotonin 5-HT2 receptorsInsomnia, sexual dysfunction, agitation
Stimulation of serotonin 5-HT3 receptorsGastrointestinal effects
Blockade of M1 muscarine receptorsDry mouth, confusion, tachycardia
Urinary retention
Blockade of H1 histamine receptorsSedation, weight gain