Table 4

Receptor profile57 and epileptogenic potential of antidepressant drugs

*Information from premarketing trials and product monograph.
0, no or negligible effect; +, stimulation,; −, blockade; Hl, histamine; Ml, muscarine; NA, noradrenaline; 5-HT1, 5-HT2, 5-HT3, serotonin receptors.
DrugAction on receptor :Seizures/epilepsy
H1M1NA5-HT15-HT25-HT3
Imipramine++++0.1–4%37–39
In overdose36: 3.8–8%
Paroxetine6566000+++Prolonged seizures during ECT58:
In overdose59: no seizures in 15 patients with maximum dose 850 mg
Sertraline67000+++Rare reports of seizures secondary to SIADH60
In overdose: no seizures in 40 patients up to 8000 mg61
Fluoxetine000+++<0.1%34*
Citalopram000+++No worsening of epilepsy in 16 patients62
In overdose63:100–1.9 g : 18% seizures 1.9 g:49%
Reboxetine00/−+0000.13%46*
Venlafaxine00++++0.18%*
In overdose64:Seizures in dosages over 1000 mg
Nefazodone000++No seizures in premarketing trials, since then rare reports of convulsions*
Mirtazepine0++<0.1%54*