Table 1

Features distinguishing multiple sclerosis from age related and vascular causes in MRI

Multiple sclerosis Ischaemia/age
Periventricular distributionWhite and grey matter lesions including basal ganglia
Ovoid lesions long axis 90° to plane of lateral ventricles/point to cortex
Subcortical lesions involve U fibres
Infratentorial lesions (brainstem/cerebellum)
Corpus callosum lesions typicalCorpus callosum lesions rare
Spinal cord lesions commonSpinal cord lesions rare