Table 4

Significance (p values4-150) of ROI MTR differences between all investigated groups

Location Familial MS v control Sporadic MS v control Familial v sporadic MS
Centrum semiovale4-151 0.000144-152 0.000060.00014
Corpus callosum (genu)0.000060.000140.00014
Corpus callosum (splenium)0.000060.108670.00014
Frontal white matter4-151 0.000144-152 0.000060.00014
Occipital white matter4-151 0.000060.000140.00014
Internal capsule4-151 0.000060.000140.00014
Cerebral peduncle4-151 0.000140.00048§ 0.00006
Cerebellar peduncle4-151 0.000060.000140.00014
Cerebellum4-151 0.000060.000140.00014

  • MS=Multiple sclerosis.

  • ↵4-150 Multiple comparison test.

  • ↵4-151 For the hemispheric regions, both right and left hemisphere values for MTR were included in the analysis.

  • All values indicate lower MTR in both MS groupsv control and lower MTR in familial MS patients v sporadic MS patients with the exception,:

  • ↵4-152 MTR higher in familial than in sporadic MS patients and§MTR higher in sporadic MS patients than in controls.