Association between cerebral haemodynamic variables and depressive symptoms
| Non-depressed (n=1977) | CES-D score ≥16 (n=116) | |||
|---|---|---|---|---|
| Mean | Mean | Adjusted difference (95% CI) | p Value | |
| Analysis of covariance with haemodynamic data entered as continuous variables and adjusted for age, sex, education, cognitive function, smoking, systolic and diastolic blood pressure, antidepressant and antihypertensive drug treatment, total cholesterol, diabetes mellitus, and history of stroke. | ||||
| Values are unadjusted means and adjusted differences, using pairwise comparison with non-depressed reference group. | ||||
| CI, confidence interval; CES-D, Center for Epidemiology Studies depression scale. | ||||
| Blood flow velocity (cm/s) | ||||
| End diastolic | 32.5 | 29.6 | −2.3 (−3.9 to −0.7) | 0.005 |
| Mean | 50.5 | 47.8 | −2.9 (−5.0 to −0.8) | 0.008 |
| Peak systolic | 86.5 | 82.5 | −4.2 (−7.6 to −0.7) | 0.02 |
| Vasomotor reactivity (%/kPa) | 3.9 | 3.1 | −0.5 (−1.0 to −0.05) | 0.03 |