Table 2

Nerve biopsy results in hereditary brachial plexus neuropathy

PatientNerveInflammation*DistributionAxonal degenerationIn situ hybridisation†Density of myelinated fibresOther
*Collections of mononuclear inflammatory cells: individual, <10 cells; small, 10–49 cells; moderate, 50–99 cells; large, ≥100 cells.
†For cytomegalovirus, Epstein–Barr virus, varicella-zoster virus, and herpes simplex virus.
1Radial sensoryMononuclear multiple infiltrates (moderate)Epineurial (perivascular); vessel wall involvement/ destructionMarked (17%); multifocalNo hybridisationSlightly reducedRare early onion bulbs; frequent regenerating clusters; thin myelin
2Radial sensoryMononuclear multiple infiltrates (small)Epineurial; endoneurial; subperineurial (perivascular); vessel wall involvement/ destructionSevere (95%)No hybridisationModerately reducedDiffuse axonal degeneration; regenerating clusters; thin myelin
3Median motor (single fascicle)NoneNot applicableNoneNo hybridisationNormalFrequent intervascular neutrophils, probably preparatory
4Radial sensoryMononuclear infiltrate (individual)Epineurial; perivascularNoneNo hybridisationNormalThin myelin; regenerating clusters