Nerve biopsy results in hereditary brachial plexus neuropathy
| Patient | Nerve | Inflammation* | Distribution | Axonal degeneration | In situ hybridisation† | Density of myelinated fibres | Other |
|---|---|---|---|---|---|---|---|
| *Collections of mononuclear inflammatory cells: individual, <10 cells; small, 10–49 cells; moderate, 50–99 cells; large, ≥100 cells. | |||||||
| †For cytomegalovirus, Epstein–Barr virus, varicella-zoster virus, and herpes simplex virus. | |||||||
| 1 | Radial sensory | Mononuclear multiple infiltrates (moderate) | Epineurial (perivascular); vessel wall involvement/ destruction | Marked (17%); multifocal | No hybridisation | Slightly reduced | Rare early onion bulbs; frequent regenerating clusters; thin myelin |
| 2 | Radial sensory | Mononuclear multiple infiltrates (small) | Epineurial; endoneurial; subperineurial (perivascular); vessel wall involvement/ destruction | Severe (95%) | No hybridisation | Moderately reduced | Diffuse axonal degeneration; regenerating clusters; thin myelin |
| 3 | Median motor (single fascicle) | None | Not applicable | None | No hybridisation | Normal | Frequent intervascular neutrophils, probably preparatory |
| 4 | Radial sensory | Mononuclear infiltrate (individual) | Epineurial; perivascular | None | No hybridisation | Normal | Thin myelin; regenerating clusters |