Clinical and neuroradiological features of patients with or without cognitive impairment
| Cognitive impairment (+) (n=46) | Cognitive impairment (−) (n=208) | p Value | |
|---|---|---|---|
| *Left ventricular hypertrophy, ischaemic change, or atrial fibrillation. | |||
| Statistics were by unpaired t test or χ2 test; values are mean (SD);WML, white matter lesion. | |||
| Age (y) | 78.0 (6.3) | 72.9 (6.6) | <0.0001 |
| Sex (M/F) | 11/35 | 58/150 | 0.5837 |
| Educational level (y) | 7.4 (1.3) | 8.7 (1.9) | <0.0001 |
| History of hypertension (+) | 24 (52)% | 68 (33)% | 0.0140 |
| History of diabetes mellitus (+) | 3 (7)% | 10 (5)% | 0.6331 |
| Systolic blood pressure (mm Hg) | 159.0 (26.3) | 144.6 (23.0) | 0.0002 |
| Diastolic blood pressure (mm Hg) | 76.9 (9.9) | 75.7 (10.3) | 0.4953 |
| Blood chemistry: | |||
| Packed cell volume | 0.36 (0.04) | 0.39 (0.04) | 0.0012 |
| Albumin (g/l) | 42.4 (3.4) | 43.0 (2.7) | 0.1923 |
| Fasting blood glucose (mmol/l) | 5.32 (1.20) | 5.22 (1.28) | 0.6353 |
| Total cholesterol (mmol/l) | 4.89 (1.17) | 5.07 (0.83) | 0.2130 |
| HDL cholesterol (mmol/l) | 1.45 (0.30) | 1.51 (0.37) | 0.2800 |
| Abnormal neurological signs (+) | 4 (9)% | 12 (6)% | 0.4597 |
| Abnormal ECG (+)* | 11 (24)% | 32 (15)% | 0.1628 |
| MRI findings: | |||
| %WML (%) | 8.25 (4.40) | 5.03 (4.25) | <0.0001 |
| %Brain (%) | 79.0 (5.8) | 83.1 (6.3) | <0.0001 |
| Cerebral infarction (+) | 16 (35)% | 38 (18)% | 0.0130 |
| (No per case) | 1.65 (1.04) | 1.65 (1.01) | 0.0302 |