Clinical and neuropsychological characteristics of subjects with Alzheimer’s disease (n = 9) and healthy controls (n = 10)
| Alzheimer’s disease | Healthy controls | Statistical test | Significance | |
|---|---|---|---|---|
| CAMCOG: Cambridge cognitive examination for the elderly31; FOME: Fuld object-memory evaluation35; MADRS: Montgomery-Asberg depression rating scale56; MMSE: mini-mental state examination.32 | ||||
| Clinical variables | ||||
| Sex (M:F) | 7:2 | 6:4 | χ2=0.69 | p=0.405 |
| Age (years) (mean (SD), range) | 70 (7.75), 62 to 82 | 70.10 (5.65), 64 to 79 | t=−0.03 | p=0.975 |
| Handedness (right:non-right) | 9:0 | 9:1 | χ2=0.95 | p=0.330 |
| Years of education (mean (SD)) | 10.67 (3.08) | 6.90 (4.63) | t=2.06 | p=0.055 |
| Social class (A/B/C/D/E) | 0/6/3/0/0 | 0/2/5/3/0 | χ2=5.46 | p=0.065 |
| MMSE (mean (SD), range) | 21.78 (1.86), 18 to 25 | 29.10 (0.57), 28 to 30 | t=−11.91 | p<0.001 |
| MADRS (mean (SD), range) | 13.11 (5.67), 4 to 22 | 2.60 (2.99), 0 to 8 | t=5.14 | p<0.001 |
| Scores on neuropsychological tests | ||||
| CAMCOG (mean (SD)) | ||||
| Language comprehension | 8.11 (0.93) | 8.80 (0.63) | t=−1.91 | p=0.073 |
| Praxis | 9.89 (1.17) | 11.00 (1.25) | t=−1.99 | p=0.062 |
| Remote memory | 3.22 (1.64) | 5.00 (0.94) | t=−2.93 | p=0.009 |
| Recent memory | 1.44 (1.24) | 3.50 (0.71) | t=−4.51 | p<0.001 |
| Category fluency (mean (SD)) | 10.33 (3.00) | 13.90 (3.7) | t=−2.29 | p=0.035 |
| FOME delayed recall (mean (SD)) | 4.89 (3.89) | 9.75 (0.46) | t=−3.50 | p=0.003 |