Side effects observed
| Group | Combination (n (%)) | Control (n (%)) |
|---|---|---|
| Total | 69 | 69 |
| Constipation | 32 (46) | 10 (14) |
| Mouth dry | 22 (32) | 7 (10) |
| Nausea | 13 (19) | 6 (9) |
| Insomnia | 13 (19) | 4 (6) |
| Depression | 12 (17) | 9 (13) |
| Headache | 10 (14) | 13 (19) |
| Palpitations | 9 (13) | 2 (3) |
| Urinary tract infections | 9 (13) | 14 (20) |
| Fatigue | 8 (12) | 12 (17) |
| Hot flushes | 8 (12) | 1 (1.5) |
| Diarrhoea | 2 (3) | 7 (10) |
| Back pain | 2 (3) | 6 (9) |